Pure Genes, Pure Genius
نویسنده
چکیده
The 2012 Albert Lasker Special Achievement Award in Medical Science will be shared by Donald Brown and Tom Maniatis for their scientific work leading to the purification and study of single genes by physical and molecular biological methodologies. Brown and Maniatis are also recognized for their extraordinary commitment and generosity in promoting the careers of young scientists. The impact of these accomplishments has transformed biological and medical science over the past four decades.
منابع مشابه
Genomic organization of purK and purE in Brevibacterium ammoniagenes ATCC 6872: purE locus provides a clue for genomic evolution.
From the genomic library of Brevibacterium ammoniagenes ATCC6872, the purE locus encoding 5'-phosphoribosyl-5-aminoimidazole (AIR) carboxylase (EC 4.1.1.21) was cloned and its nucleotide sequence was determined. From the sequence analysis, two distinct open reading frames (ORFs) in the sequence of the purE locus were identified as purK and purE genes (purK-purE). An in vivo translation experime...
متن کامل$(m,n)$-algebraically compactness and $(m,n)$-pure injectivity
In this paper, we introduce the notion of $(m,n)$-algebraically compact modules as an analogue of algebraically compact modules and then we show that $(m,n)$-algebraically compactness and $(m,n)$-pure injectivity for modules coincide. Moreover, further characterizations of a $(m,n)$-pure injective module over a commutative ring are given.
متن کاملMolecular Analysis of Mixed Endometrioid and Serous Adenocarcinoma of the Endometrium
BACKGROUND The molecular biology and cellular origins of mixed type endometrial carcinomas (MT-ECs) are poorly understood, and a Type II component of 10 percent or less may confer poorer prognoses. METHODOLOGY/PRINCIPAL FINDINGS We studied 10 cases of MT-EC (containing endometrioid and serous differentiation), 5 pure low-grade endometrioid adenocarcinoma (EAC) and 5 pure uterine serous carcin...
متن کاملA NEW CHARACTERIZATION OF ABSOLUTELY PO-PURE AND ABSOLUTELY PURE S-POSETS
In this paper, we investigate po-purity using finitely presented S-posets, and give some equivalent conditions under which an S-poset is absolutely po-pure. We also introduce strongly finitely presented S-posets to characterize absolutely pure S-posets. Similar to the acts, every finitely presented cyclic S-posets is isomorphic to a factor S-poset of a pomonoid S by a finitely generated right con...
متن کاملGenomic differences between pure ductal carcinoma in situ and synchronous ductal carcinoma in situ with invasive breast cancer
Although ductal carcinoma in situ (DCIS) precedes invasive ductal carcinoma (IDC), the related genomic alterations remain unknown. To identify the genomic landscape of DCIS and better understand the mechanisms behind progression to IDC, we performed whole-exome sequencing and copy number profiling for six cases of pure DCIS and five pairs of synchronous DCIS and IDC. Pure DCIS harbored well-kno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell
دوره 150 شماره
صفحات -
تاریخ انتشار 2012